REVISTA

Historia y farmacología del opioide fentanilo.

Valoración Valoración: 3 Estrellas

Descripción: Historia y farmacología del fentanilo, incluyendo la solución transdérmica de larga duración para su uso en perros.

TITULO FUENTE ORIGINAL:

The history and pharmacology of fentanyl: relevance to a novel, long-acting transdermal fentanyl solution newly approved for use in dogs

AUTORES:

B. Kukanich, T. P. Clark

REVISTA ABREV.:

J. vet. Pharmacol. Therap

AÑO:

2012

REFERENCIA:

35 (Suppl. 2), 3–19

DOI:

10.1111/j.1365-2885.2012.01416.x.

RESUMEN ORIGINAL:

Fentanyl is a potent mu opioid receptor agonist that was discovered to identifyan improved human health analgesic over morphine, an opioid frequentlyassociated with histamine-release, bradycardia, hyper- or hypotension, andprolonged postoperative respiratory depression. Historically, the pharmacological features of fentanyl have been described primarily through the... + Leer más

Fentanyl is a potent mu opioid receptor agonist that was discovered to identifyan improved human health analgesic over morphine, an opioid frequentlyassociated with histamine-release, bradycardia, hyper- or hypotension, andprolonged postoperative respiratory depression. Historically, the pharmacological features of fentanyl have been described primarily through the study of thehuman approved fentanyl citrate formulation. In conscious dogs, fentanyl has awide margin of safety, possesses minimum effects on the cardiovascular andrespiratory systems, and is readily reversible. Other pharmacological featuresinclude sedation, mild reductions in body temperature, and dose-dependentreduction in food intake. The short duration of effect of available fentanyl citratesolutions has limited its clinical use to perioperative injections or constant rateinfusions (CRIs). To extend the analgesic effect, additional fentanyl deliverytechnologies have been developed for human health including the fentanylpatch that has been used in an extra-label manner in dogs. Beyond the slowonset and variability in fentanyl delivery, several additional disadvantages haveprecluded common use of patches in dogs. The recent approval of long-actingtransdermal fentanyl solution for dogs provides a new approach for sustaineddelivery of fentanyl for the control of postoperative pain in dogs. It has a rapidonset of action, prolonged duration, and mitigates the disadvantages of oral,parenteral, and patch-delivered opioids. The availability of a safe and effectiveapproved opioid in dogs may allow further optimization of postoperativeanalgesia in this species. The objective of this review is to summarize the historyand pharmacology of fentanyl and to integrate information about the newlyapproved long-acting transdermal fentanyl solution.

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