REVISTA

El sistema endotelina: una nueva diana terapéutica del dolor crónico

Descripción: La endotelina-1 puede sr un nuevo objetivo para el tratamiento del dolor crónico.

TITULO FUENTE ORIGINAL:

Evidence for the endothelin system as an emerging therapeutic target for the treatment of chronic pain

AUTORES:

Smith TP, Haymond T, Smith SN, Sweitzer SM

REVISTA ABREV.:

J Pain Res

AÑO:

2014

REFERENCIA:

7:531-45

DOI:

10.2147/JPR.S65923

FECHA DE PUBLICACIÓN:

03/09/2014

RESUMEN ORIGINAL:

Many people worldwide suffer from pain and a portion of these sufferers are diagnosed with a chronic pain condition. The management of chronic pain continues to be a challenge, and despite taking prescribed medication for pain, patients continue to have pain of moderate severity. Current pain therapies are often inadequate, with side effects that limit medication adherence. There is a need to... + Leer más

Many people worldwide suffer from pain and a portion of these sufferers are diagnosed with a chronic pain condition. The management of chronic pain continues to be a challenge, and despite taking prescribed medication for pain, patients continue to have pain of moderate severity. Current pain therapies are often inadequate, with side effects that limit medication adherence. There is a need to identify novel therapeutic targets for the management of chronic pain. One potential candidate for the treatment of chronic pain is therapies aimed at modulating the vasoactive peptide endothelin-1. In addition to vasoactive properties, endothelin-1 has been implicated in pain transmission in both humans and animal models of nociception. Endothelin-1 directly activates nociceptors and potentiates the effect of other algogens, including capsaicin, formalin, and arachidonic acid. In addition, endothelin-1 has been shown to be involved in inflammatory pain, cancer pain, neuropathic pain, diabetic neuropathy, and pain associated with sickle cell disease. Therefore, endothelin-1 may prove a novel therapeutic target for the relief of many types of chronic pain.

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