REVISTA

Antinocicepción de la buspirona en un modelo canino de dolor abdominal

Valoración Valoración: 3 Estrellas

Descripción: La activación de los receptores 5-HT1A inhibe la sensibilidad al dolor visceral y tiene un posible efecto excitatorio sobre el sistema cardiovascular.

TITULO FUENTE ORIGINAL:

Antinociceptive effect of the agonist of 5-HT1A receptors buspirone in the model of abdominal pain in dogs

AUTORES:

Lyubashina OA, Busygina II, Panteleev SS, Nozdrachev AD

REVISTA ABREV.:

Dokl Biol Sci

AÑO:

2017

REFERENCIA:

473(1):46-49

DOI:

10.1134/S0012496617020119

RESUMEN ORIGINAL:

We have demonstrated that activation of 5-HT1A receptors with buspirone promotes visceral analgesia in awake dogs. The administration of 0.035 mg/kg (i.m.) of the drug caused depression of viscero-motor (contraction of the abdominal muscles) and pressor (increase in the heart rate) responses to noxious distension of the large intestine. An increase in the dose to 0.07 and 0.14 mg/kg did not... + Leer más

We have demonstrated that activation of 5-HT1A receptors with buspirone promotes visceral analgesia in awake dogs. The administration of 0.035 mg/kg (i.m.) of the drug caused depression of viscero-motor (contraction of the abdominal muscles) and pressor (increase in the heart rate) responses to noxious distension of the large intestine. An increase in the dose to 0.07 and 0.14 mg/kg did not enhance the antinociceptive effect of buspirone but triggered basal tachycardia. The obtained results provide evidence of the inhibitory role of 5-HT1A receptors in modulating visceral pain sensitivity and the possibility of an exciting effect of their activation on the cardiovascular system.

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Enlace a revista: https://link.springer.com/article/10.1134%2FS[...]