REVISTA

Robenacoxib subcutáneo para el tratamiento del dolor en cirugía de tejidos blandos

Valoración Valoración: 4 Estrellas

Descripción: El robenacoxib subcutáneo es eficaz y bien tolerado para el control de la inflamación y el dolor postoperatorio en perros.

TITULO FUENTE ORIGINAL:

Efficacy and safety of injectable Robenacoxib for the treatment of pain associated with soft tissue surgery in dogs

AUTORES:

Friton G, Thompson C, Karadzovska D, King S, King JN

REVISTA ABREV.:

J Vet Intern Med

AÑO:

2017

REFERENCIA:

31(3):832-841

DOI:

10.1111/jvim.14698

RESUMEN ORIGINAL:

BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) are used routinely to control pain and inflammation after surgery in dogs. Robenacoxib is a cyclooxygenase-2 selective NSAID.
HYPOTHESIS/OBJECTIVE: Assess the clinical efficacy and safety of an injectable formulation of robenacoxib in dogs undergoing surgery.
ANIMALS: Three hundred and seventeen client-owned...
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BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) are used routinely to control pain and inflammation after surgery in dogs. Robenacoxib is a cyclooxygenase-2 selective NSAID.
HYPOTHESIS/OBJECTIVE: Assess the clinical efficacy and safety of an injectable formulation of robenacoxib in dogs undergoing surgery.
ANIMALS: Three hundred and seventeen client-owned dogs (N = 159 robenacoxib or N = 158 placebo).
METHODS: In this prospective, multicenter, randomized, masked, placebo-controlled, parallel-group study, dogs received a SC injection of either robenacoxib, at a target dose of 2.0 mg/kg, or placebo once prior to surgery and for 2 additional days postoperatively. Pain assessments were performed using the short form of the Glasgow Composite Measure Pain Scale (CMPS-SF). The primary efficacy variable was treatment success/failure, with failure defined as the need for rescue therapy to control pain or withdrawal of the dog from the study due to an adverse event.
RESULTS: Significantly (P = .006) more dogs administered robenacoxib were considered treatment successes (108 of 151, 73.7%) compared to dogs given placebo (85 of 152, 58.1%). Total pain scores (P < .01), pain at the surgery sites (response to touch, P < .01), and posture/activity (P < .05) were significantly improved at 3, 5, and 8 hours postextubation in dogs receiving robenacoxib versus placebo.
CONCLUSIONS AND CLINICAL IMPORTANCE: Robenacoxib administered by SC injection prior to surgery and for 2 additional days postoperatively was effective and well tolerated in the control of postoperative pain and inflammation associated with soft tissue surgery in dogs.

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Enlace a revista: http://onlinelibrary.wiley.com/doi/10.1111/jv[...]