REVISTA

Reacción adversa a apomorfina en un Collie con mutación MDR1

Valoración Valoración: 3 Estrellas

Descripción: La apomorfina podría ser un sustrato de la glicoproteína P, tras una excesiva depresión del SNC registrada en un collie tras aplicación subconjuntival

TITULO FUENTE ORIGINAL:

Adverse reaction to apomorphine in a Collie homozygous for the ABCB1-1∆ (MDR1) mutation

AUTORES:

Campbell O, de Lorimier LP, Mealey KL

REVISTA ABREV.:

J Small Anim Pract

AÑO:

2017

DOI:

10.1111/jsap.12618

RESUMEN ORIGINAL:

A nine-month-old 30 kg spayed female rough collie and two other dogs, an eight-month 31·5 kg intact male Belgian shepherd and a 2·5-year 52 kg neutered male Bernese mountain dog, were presented shortly after ingestion of an unknown quantity of acetaminophen tablets by at least one of the dogs. Vomiting was induced by administering 2 mg apomorphine in the conjunctival sac of each... + Leer más

A nine-month-old 30 kg spayed female rough collie and two other dogs, an eight-month 31·5 kg intact male Belgian shepherd and a 2·5-year 52 kg neutered male Bernese mountain dog, were presented shortly after ingestion of an unknown quantity of acetaminophen tablets by at least one of the dogs. Vomiting was induced by administering 2 mg apomorphine in the conjunctival sac of each dog. Emesis was more severe in the collie (number of events and duration), and she experienced greater central nervous system (CNS) depression compared to both other dogs despite conjunctival rinsing, but recovered completely from this episode. MDR1 genotyping identified the collie as MDR1 mutant/mutant (homozygous for the ABCB1-1∆ gene mutation) while the other two dogs were MDR1 normal/normal.Although apomorphine has not been described as a P-glycoprotein substrate, other opioids, including loperamide and butorphanol, are known substrates for canine P-glycoprotein (Mealey & Fidel 2015). Dogs affected by the MDR1 mutation experience exaggerated CNS depression compared to MDR1 wildtype dogs when treated with these drugs because defective P-glycoprotein allows greater brain penetration. Similarly, the collie described here experienced exaggerated CNS depression compared to the other dogs suggesting greater CNS penetration of apomorphine. While this report suggests that apomorphine may be a substrate for P-glycoprotein, further investigation would be necessary to confirm this. However, it may be prudent to avoid apomorphine as an emetic in dogs with the MDR1 mutation.

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