REVISTA

Farmacocinética de la buprenorfina en infusión continua intravenosa en perros

Valoración Valoración: 4 Estrellas

Descripción: La buprenorfina en CRI proporciona buena analgesia postoperatoria en perras sometidas a ovariectomía, con menos efectos adversos que los bolos frecuentes.

TITULO FUENTE ORIGINAL:

Pharmacokinetics of buprenorphine following constant rate infusion for postoperative analgesia in dogs undergoing ovariectomy

AUTORES:

Barbarossa A, Rambaldi J, Giunti M, Zaghini A, Cunto M, Zambelli D, Valgimigli S, Santoro F, Romagnoli N

REVISTA ABREV.:

Vet Anaesth Analg

AÑO:

2017

REFERENCIA:

1-9

DOI:

10.1016/j.vaa.2016.05.010

RESUMEN ORIGINAL:

OBJECTIVE: To investigate the pharmacokinetics of buprenorphine and its main active metabolite, norbuprenorphine, after administration of an intravenous loading dose followed by constant rate infusion (CRI) in dogs.
STUDY DESIGN: Prospective, clinical study.
ANIMALS: A total of seven healthy dogs undergoing elective ovariectomy.
METHODS: Buprenorphine was...
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OBJECTIVE: To investigate the pharmacokinetics of buprenorphine and its main active metabolite, norbuprenorphine, after administration of an intravenous loading dose followed by constant rate infusion (CRI) in dogs.
STUDY DESIGN: Prospective, clinical study.
ANIMALS: A total of seven healthy dogs undergoing elective ovariectomy.
METHODS: Buprenorphine was administered as a loading dose (intravenous bolus of 15 μg kg-1) followed by CRI (2.5 μg kg-1 hour-1 for 6 hours). Moreover, intraoperative analgesia was supplemented by an intramuscular carprofen (4 mg kg-1) injection, administered prior to surgery, and by lidocaine, administrated through subcutaneous infiltration and through a splash on the ovarian vascular pedicle during surgery. Pain and sedation were scored for all animals throughout the 24-hour study period and rescue analgesia was administered when a visual analogue scale score was > 40 mm. Blood samples were collected from a jugular catheter at regular intervals, and plasma concentrations of buprenorphine and norbuprenorphine were determined by a validated liquid chromatography-tandem mass spectrometry method.
RESULTS: Buprenorphine showed a two-compartment kinetic profile. Maximum concentration was 23.92 ± 8.64 ng mL-1 at 1 minute (maximum time); elimination half-life was 41.87 ± 17.35 minutes; area under the curve was 486.68 ± 125.66 minutes ng-1 mL-1; clearance was 33.61 ± 13.01 mL minute-1 kg-1, and volume of distribution at steady state was 1.77 ± 0.50 L kg-1. In no case was rescue analgesia required. Norbuprenorphine resulted below the lower limit of quantification in almost all samples.
CONCLUSIONS AND CLINICAL RELEVANCE: The results suggest that a buprenorphine CRI can be a useful tool for providing analgesia in postoperative patients, considering its minor side effects and the advantages of a CRI compared to frequent boluses. The negligible contribution of norbuprenorphine to the therapeutic effect was confirmed.

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