REVISTA

Fentanilo en la hemorragia cerebral en ratas

Valoración Valoración: 3 Estrellas

Descripción: Evaluación de dosis efectivas en el tratamiento del dolor y sus efectos secundarios en la hemorragia cerebral inducida en ratas.

TITULO FUENTE ORIGINAL:

Effects of fentanyl on pain and motor behaviors following a collagenase-induced intracerebral hemorrhage in rats

AUTORES:

Saine L, Hélie P, Vachon P

REVISTA ABREV.:

J Pain Res

AÑO:

2016

REFERENCIA:

9:1039-1048

DOI:

10.2147/JPR.S121415

RESUMEN ORIGINAL:

PURPOSE:Intracerebral hemorrhage (IH) and cephalalgia are common consequences of traumatic brain injury. One of the primary obstacles for patient recovery is the paucity of treatments to support an appropriate analgesic protocol. The present study aimed to assess pain and motor behaviors following different doses of fentanyl on a rat model of IH.
METHODS:Twenty-one male Sprague Dawley...
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PURPOSE:Intracerebral hemorrhage (IH) and cephalalgia are common consequences of traumatic brain injury. One of the primary obstacles for patient recovery is the paucity of treatments to support an appropriate analgesic protocol. The present study aimed to assess pain and motor behaviors following different doses of fentanyl on a rat model of IH.
METHODS:Twenty-one male Sprague Dawley rats underwent a stereotaxic surgery to produce a collagenase-induced IH in the right caudoputamen nucleus. The control group (n=6) received saline subcutaneously (SC), and experimental groups received either 5 (n=6), 10 (n=6), or 20 (n=3) µg/kg of fentanyl SC, 2 hours following surgery and on 2 subsequent days. Only 3 animals received 20 µg/kg because this dose caused catalepsy for 15-20 minutes following the injection. The rat grimace scale, a neurological examination, balance beam test, and rotarod test were performed for 5 consecutive days postoperatively to evaluate pain and motor performance. At the end of the experimentation, the brains were evaluated to determine hematoma volume, and the number of reactive astrocytes and necrotic neurons.
RESULTS:When compared to controls, the grimace scale showed that 5 µg/kg fentanyl significantly alleviated pain on day 2 only (P<0.01) and that 10 µg/kg alleviated pain on days 1 (P<0.01), 2 (P<0.001), and 3 (P<0.01). For the rotarod test, only the 10 µg/kg group showed significant decreases in performance on days 5 (P<0.05) and 6 (P<0.02). The neurological examination was not significantly different between the groups, but only the hopping test showed poor recuperation for the 5 and 10 µg/kg fentanyl group when compared to saline (P<0.01). No differences were found between the groups for the balance beam test, the histopathological results.
CONCLUSION:Fentanyl, at a dose of 10 µg/kg SC, provides substantial analgesia following a collagenase-induced IH in rats; however, it can alter motor performance following analgesic treatments.

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ENLACES DE INTERÉS

Enlace contenido de libre acceso:: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC[...]

Enlace contenido de libre acceso:: https://www.dovepress.com/effects-of-fentanyl[...]