REVISTA

Eficacia analgésica de una formulación de aerosol por vía transmucosa oral de meloxicam solo o en combinación con tramadol en gatos con artrosis

Valoración Valoración: 3 Estrellas

Descripción: Evaluación de la eficacia analgésica de meloxicam de pulverización por vía transmucosa oral (OTMS) solo y con tramadol en gatos con osteoartritis (OA).

TITULO FUENTE ORIGINAL:

Analgesic efficacy of an oral transmucosal spray formulation of meloxicam alone or in combination with tramadol in cats with naturally occurring osteoarthritis

AUTORES:

Monteiro BP, Klinck MP, Moreau M, Guillot M, Steagall PV, Edge DK, Pelletier JP, Martel-Pelletier J, Gauvin D, Del Castillo JR, Troncy E

REVISTA ABREV.:

Vet Anaesth Analg.

AÑO:

2016

DOI:

10.1111/vaa.12360

FECHA DE PUBLICACIÓN:

24/02/2016

RESUMEN ORIGINAL:

Abstract
OBJECTIVE:
To evaluate the analgesic efficacy of meloxicam oral transmucosal spray (OTMS) alone and with tramadol in cats with osteoarthritis (OA).
STUDY DESIGN:
Randomized, blinded study.
ANIMALS:
Fifteen geriatric cats weighing 4.5 ± 1.0 kg.
METHODS:
Healthy cats with OA were randomly administered a placebo (every 12 hours orally) and...
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Abstract
OBJECTIVE:
To evaluate the analgesic efficacy of meloxicam oral transmucosal spray (OTMS) alone and with tramadol in cats with osteoarthritis (OA).
STUDY DESIGN:
Randomized, blinded study.
ANIMALS:
Fifteen geriatric cats weighing 4.5 ± 1.0 kg.
METHODS:
Healthy cats with OA were randomly administered a placebo (every 12 hours orally) and meloxicam OTMS (approximately 0.05 mg kg-1 every 24 hours) (group M, n = 7), or tramadol (3 mg kg-1 every 12 hours orally) and meloxicam OTMS (group TM, n = 8) for 25 days. Evaluations performed before treatment (D0) and at week 3 (W3) consisted of peak vertical force, motor activity and response to mechanical temporal summation of pain (RMTS). Data were analyzed with mixed models and Fisher's exact test.
RESULTS:
Mean ± standard deviation peak vertical force (percentage of body weight) increased significantly in both groups (p = 0.02), from 47.7 ± 6.5% to 60.5 ± 9.4% in group M, and from 51.8 ± 5.0% to 64.1 ± 6.5% in group TM, with no difference between groups. Motor activity increased in M (from 43 ± 12 to 56 ± 13; p = 0.02), but not in TM. The number of stimulations from RMTS increased in TM only. Cut-off values were reached in a larger number of cats (n = 5) in TM than M (n = 1) (p < 0.05). Gastrointestinal adverse effects were self-limiting in six cats, including five in TM.
CONCLUSIONS AND CLINICAL RELEVANCE:
Meloxicam OTMS had similar effects on peak vertical force, motor activity and pain sensitization as previously reported for oral meloxicam in OA cats. The tramadol-meloxicam combination provided no evident benefit over meloxicam alone, except for central hypersensitivity (assessed with RMTS). Further assessment of the potential toxicity of the combination is required prior to clinical use. Gingival administration was well accepted overall.

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