REVISTA DESTACADA

Extracto de oliva y semilla de uva como prevención de la osteoartrosis

Valoración Valoración: 4 Estrellas

Descripción: El contenido en hidroxitirosol y procianidinas de la oliva y las semillas de la uva parecen ejercer un importante efecto antiinflamatorio y condroprotector.

TITULO FUENTE ORIGINAL:

Olive and grape seed extract prevents post-traumatic osteoarthritis damages and exhibits in vitro anti IL-1β activities before and after oral consumption

AUTORES:

Mével E, Merceron C, Vinatier C, Krisa S, Richard T, Masson M, Lesoeur J, Hivernaud V, Gauthier O, Abadie J, Nourissat G, Houard X, Wittrant Y, Urban N, Beck L, Guicheux J

REVISTA ABREV.:

Sci Rep.

AÑO:

2016

REFERENCIA:

6:33527

DOI:

10.1038/srep33527.

RESUMEN ORIGINAL:

Polyphenols exert a large range of beneficial effects in the prevention of age-related diseases. We sought to determine whether an extract of olive and grape seed standardized according to hydroxytyrosol (HT) and procyanidins (PCy) content, exerts preventive anti-osteoathritic effects. To this aim, we evaluated whether the HT/PCy mix could (i) have in vitro anti-inflammatory and... + Leer más

Polyphenols exert a large range of beneficial effects in the prevention of age-related diseases. We sought to determine whether an extract of olive and grape seed standardized according to hydroxytyrosol (HT) and procyanidins (PCy) content, exerts preventive anti-osteoathritic effects. To this aim, we evaluated whether the HT/PCy mix could (i) have in vitro anti-inflammatory and chondroprotective actions, (ii) exert anti-osteoarthritis effects in two post-traumatic animal models and (iii) retain its bioactivity after oral administration. Anti-inflammatory and chondroprotective actions of HT/PCy were tested on primary cultured rabbit chondrocytes stimulated by interleukin-1 beta (IL-1β). The results showed that HT/PCy exerts anti-inflammatory and chondroprotective actions in vitro. The preventive effect of HT/PCy association was assessed in two animal models of post-traumatic OA in mice and rabbits. Diet supplementation with HT/PCy significantly decreased the severity of post-traumatic osteoarthritis in two complementary mice and rabbit models. The bioavailability and bioactivity was evaluated following gavage with HT/PCy in rabbits. Regular metabolites from HT/PCy extract were found in sera from rabbits following oral intake. Finally, sera from rabbits force-fed with HT/PCy conserved anti-IL-1β effect, suggesting the bioactivity of this extract. To conclude, HT/PCy extract may be of clinical significance for the preventive treatment of osteoarthritis.

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COMENTARIO

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ENLACES DE INTERÉS

Enlace: : http://www.nature.com/articles/srep33527