REVISTA DESTACADA

Aceite de pescado y control del dolor inflamatorio persistente

Valoración Valoración: 4 Estrellas

Descripción: Revisión de los efectos antiinflamatorios del aceite de pescado rico en ácidos grasos Omega-3 en ratas con dolor inflamatorio

TITULO FUENTE ORIGINAL:

Fish oil attenuates persistent inflammatory pain in rats through modulation of TNF-α and resolvins

AUTORES:

Lobo BW, de Lima CK, Teixeira MD, Silva NL, Takiya CM, de S Ramos MF, de Miranda AL, Dellamora-Ortiz GM

REVISTA ABREV.:

Life Sci

AÑO:

2016

REFERENCIA:

pii: S0024-3205(16)30184-9

DOI:

10.1016/j.lfs.2016.03.034.

RESUMEN ORIGINAL:

Fish oil (FO), source of omega-3 fatty acids (FA), has been widely studied in the treatment of inflammatory diseases and inflammatory pain (IP). Omega-3 FA give rise to eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids, metabolized to eicosanoids and converted to resolvins with important anti-inflammatory action.
AIMS: This study investigates the effects of oral doses of omega-3...
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Fish oil (FO), source of omega-3 fatty acids (FA), has been widely studied in the treatment of inflammatory diseases and inflammatory pain (IP). Omega-3 FA give rise to eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids, metabolized to eicosanoids and converted to resolvins with important anti-inflammatory action.
AIMS: This study investigates the effects of oral doses of omega-3 FA from FO and concentrated fish oil (CFO) in a model of sub-chronic IP, induced by Complete Freund's Adjuvant (CFA).
MAIN METHODS: IP was induced by intraplantar injection of CFA into the right hind paw of Wistar rats. Three groups were pre-treated with omega-3 FA: two groups received CFO (460mg of EPA/360mg of DHA and 690mg of EPA/540mg of DHA) and one group received natural FO (460mg EPA/300mg DHA), for 7days before IP induction (pre-treatment) and 5days after induction (treatment).
KEY FINDINGS: TNF-α levels were reduced by CFO 690 (67.9%; p<0.01), CFO 460 (57.7%; p<0.01), FO 460 (26.2%), compared to the augment promoted by CFA (549.7%; p<0.001). Resolvin levels were increased in treated groups with respect to the CFA control group (CFO 690=3196.3%, p<0.01; CFO 460=3347.1%, p<0.01; FO=1653.5%).
SIGNIFICANCE: The results indicate that the tested doses reduced inflammatory pain effectively in a short pre-treatment period, through modulation of TNF-α and resolvins and that CFO presented better results than FO. Therefore, Ω-3 FA from FO can be proposed for use as complementary medicine in the treatment of painful and inflammatory diseases.

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