REVISTA

Plasticidad y reorganización estructural neuronal en el dolor crónico

Valoración Valoración: 5 Estrellas

Descripción: Revisión centrada en los mecanismos de plasticidad o (mal)adaptación neuronal que contribuyen al desarrollo de dolor crónico

TITULO FUENTE ORIGINAL:

Structural plasticity and reorganisation in chronic pain

AUTORES:

Kuner R, Flor H

REVISTA ABREV.:

Nat Rev Neurosci

AÑO:

2016

REFERENCIA:

15;18(1):20-30

DOI:

10.1038/nrn.2016.162

RESUMEN ORIGINAL:

Chronic pain is not simply a temporal continuum of acute pain. Studies on functional plasticity in neural circuits of pain have provided mechanistic insights and linked various modulatory factors to a change in perception and behaviour. However, plasticity also occurs in the context of structural remodelling and reorganisation of synapses, cells and circuits, potentially contributing to the... + Leer más

Chronic pain is not simply a temporal continuum of acute pain. Studies on functional plasticity in neural circuits of pain have provided mechanistic insights and linked various modulatory factors to a change in perception and behaviour. However, plasticity also occurs in the context of structural remodelling and reorganisation of synapses, cells and circuits, potentially contributing to the long-term nature of chronic pain. This Review discusses maladaptive structural plasticity in neural circuits of pain, spanning multiple anatomical and spatial scales in animal models and human patients, and addresses key questions on structure-function relationships.

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ENLACES DE INTERÉS

Enlace a la editorial: : http://www.nature.com/nrn/journal/v18/n1/full[...]