REVISTA DESTACADA

Nueva estrategia antiinflamatoria y analgésica con capsazepina y aceite de mostaza

Valoración Valoración: 5 Estrellas

Descripción: La capsazepina, antagonista TRPA1, con efecto antiinflamatorio y analgésico podría convertirse en una nueva estrategia frente al dolor

TITULO FUENTE ORIGINAL:

Systemic desensitization through TRPA1 channels by capsazepine and mustard oil - a novel strategy against inflammation and pain.

AUTORES:

Kistner K, Siklosi N, Babes A, Khalil M, Selescu T, Zimmermann K, Wirtz S, Becker C, Neurath MF, Reeh PW, Engel MA

REVISTA ABREV.:

Sci Rep

AÑO:

2016

REFERENCIA:

6:28621

DOI:

10.1038/srep28621

RESUMEN ORIGINAL:

We demonstrate a novel dual strategy against inflammation and pain through body-wide desensitization of nociceptors via TRPA1. Attenuation of experimental colitis by capsazepine (CPZ) has long been attributed to its antagonistic action on TRPV1 and associated inhibition of neurogenic inflammation. In contrast, we found that CPZ exerts its anti-inflammatory effects via profound desensitization... + Leer más

We demonstrate a novel dual strategy against inflammation and pain through body-wide desensitization of nociceptors via TRPA1. Attenuation of experimental colitis by capsazepine (CPZ) has long been attributed to its antagonistic action on TRPV1 and associated inhibition of neurogenic inflammation. In contrast, we found that CPZ exerts its anti-inflammatory effects via profound desensitization of TRPA1. Micromolar CPZ induced calcium influx in isolated dorsal root ganglion (DRG) neurons from wild-type (WT) but not TRPA1-deficient mice. CPZ-induced calcium transients in human TRPA1-expressing HEK293t cells were blocked by the selective TRPA1 antagonists HC 030031 and A967079 and involved three cysteine residues in the N-terminal domain. Intriguingly, both colonic enemas and drinking water with CPZ led to profound systemic hypoalgesia in WT and TRPV1(-/-) but not TRPA1(-/-) mice. These findings may guide the development of a novel class of disease-modifying drugs with anti-inflammatory and anti-nociceptive effects.

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ENLACES DE INTERÉS

Descarga gratuita PDF: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4[...]

Web del contenido: http://www.nature.com/articles/srep28621