REVISTA DESTACADA

Papel de los queranocitos en la nocicepción

Valoración Valoración: 4 Estrellas

Descripción: La vía tópica de analgésicos en el dolor neuropático podría ser una forma local y eficaz en el tratamiento del dolor aun poco desarrollada.

TITULO FUENTE ORIGINAL:

Skin matters! The role of keratinocytes in nociception: a rational argument for the development of topical analgesics

AUTORES:

Keppel Hesselink JM, Kopsky DJ, Bhaskar AK

REVISTA ABREV.:

J Pain Res

AÑO:

2016

REFERENCIA:

10;1-8

DOI:

10.2147/JPR.S122765

RESUMEN ORIGINAL:

Abstract: Treatment of neuropathic pain using topical formulations is still in its infancy. Only few topical analgesic formulations have become available for clinical use, and among these, analgesic creams are still rare. This is unfortunate because analgesic creams offer a number of advantages over patches, such as convenience, ease of adapting the frequency of application, and dose, and... + Leer más

Abstract: Treatment of neuropathic pain using topical formulations is still in its infancy. Only few topical analgesic formulations have become available for clinical use, and among these, analgesic creams are still rare. This is unfortunate because analgesic creams offer a number of advantages over patches, such as convenience, ease of adapting the frequency of application, and dose, and “rubbing cream where it hurts” involves the patient much more in the therapeutic process compared to patches and other localized treatment modalities. Although the literature supporting the efficacy and safety of analgesic creams (mostly compounded) is growing since the last decade, most pain physicians have not yet noticed and appreciated the therapeutic potential and clinical value of these creams. This is most probably due to a prejudice that topical application should need to act transdermally, more or less as a slow-release formulation, such as in patches delivering opioids. We will discuss this prejudice and show that there are multiple important targets in the skin to be reached by topical analgesic or anti-inflammatory compounds, and that the keratinocyte is one of those targets. By specifically targeting the keratinocyte, analgesia seems possible, effective, and safe, and thus topical analgesic creams may hold promise as a novel treatment modality for neuropathic pain.

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