REVISTA DESTACADA

Efectos antinociceptivos de la exposición a la luz verde

Valoración Valoración: 4 Estrellas

Descripción: La visión de luz verde produce efectos analgésicos y antihiperalgésicos en situaciones de adolor agudo y crónico en ratas

TITULO FUENTE ORIGINAL:

Long-lasting antinociceptive effects of green light in acute and chronic pain in rats

AUTORES:

Ibrahim M; Amol P; Kerry GB.; Aubin M; Xiaofang Y; Lindsey CA.; Tally LM; Philip MT; Tood W. V; Frank P; Rajesh K

REVISTA ABREV.:

Pain

AÑO:

2017

REFERENCIA:

158(2):347-360

DOI:

10.1097/j.pain.0000000000000767

RESUMEN ORIGINAL:

Treatments for chronic pain are inadequate and new options are needed. Non-pharmaceutical approaches are especially attractive with many potential advantages including safety. Light therapy has been suggested to be beneficial in certain medical conditions such as depression, but this approach remains to be explored for modulation of pain. We investigated the effects of light emitting diodes... + Leer más

Treatments for chronic pain are inadequate and new options are needed. Non-pharmaceutical approaches are especially attractive with many potential advantages including safety. Light therapy has been suggested to be beneficial in certain medical conditions such as depression, but this approach remains to be explored for modulation of pain. We investigated the effects of light emitting diodes (LED), in the visible spectrum, on acute sensory thresholds in naive rats as well as in experimental neuropathic pain. Rats receiving green LED (wavelength 525 nanometers, 8 hours/daily) showed significantly increased paw withdrawal latency to a noxious thermal stimulus; this antinociceptive effect persisted for four days following termination of last exposure without development of tolerance. No apparent side-effects were noted and motor performance was not impaired. Despite LED exposure, opaque contact lenses prevented antinociception. Rats fitted with green contact lenses exposed to room light exhibited antinociception arguing for a role of the visual system. Antinociception was not due to stress/anxiety but likely due to increased enkephalins expression in the spinal cord. Naloxone reversed the antinociception, suggesting involvement of central opioid circuits. Rostral ventromedial medulla (RVM) inactivation prevented expression of light-induced antinociception suggesting engagement of descending inhibition. Green-LED exposure also reversed thermal and mechanical hyperalgesia in rats with spinal nerve ligation. Pharmacological and proteomic profiling of dorsal root ganglion (DRG) neurons from green-LED exposed rats identified changes in calcium channel activity, including a decrease in the N-type (CaV2.2) channel, a primary analgesic target. Thus, green-LED therapy may represent a novel, non-pharmacological approach for managing pain.

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