REVISTA

Coincidencia entre las vías biológicas activadas por la acupuntura y analgésicos

Valoración Valoración: 3 Estrellas

Descripción: La estimulación del punto de acupuntura St36 produce un efecto similar al de un bloqueante de los receptores glucocorticoides

TITULO FUENTE ORIGINAL:

Effects of Acupuncture, RU-486 on the Hypothalamic-Pituitary-Adrenal Axis in Chronically Stressed Adult Male Rats

AUTORES:

Eshkevari L, Mulroney SE, Egan R, Lao L

REVISTA ABREV.:

Endocrinology.

AÑO:

2015

REFERENCIA:

21:EN20151018

DOI:

10.1210/EN.2015-1018

FECHA DE PUBLICACIÓN:

25/07/2015

RESUMEN ORIGINAL:

We have recently reported that pretreatment with electroacupuncture (EA) at stomach meridian point 36 (St36) prevents the chronic cold-stress increase in the hypothalamus-pituitary-adrenal axis (HPA), an action that may be under central control. Given that treatment for stress-related symptoms usually begins after onset of the stress responses, the objectives of the present study were to... + Leer más

We have recently reported that pretreatment with electroacupuncture (EA) at stomach meridian point 36 (St36) prevents the chronic cold-stress increase in the hypothalamus-pituitary-adrenal axis (HPA), an action that may be under central control. Given that treatment for stress-related symptoms usually begins after onset of the stress responses, the objectives of the present study were to determine the efficacy of EA St36 on HPA hormones when EA St36 is given after stress was initiated, if the results are long lasting, and if blocking the glucocorticoid receptor (GR) using RU-486 had the same effects as EA St36. Adult male rats were placed in 4 groups of animals, 3 of which were exposed to cold and 1 of which was a nontreatment control group. After exposure to the cold stress, 2 groups were treated with either EA St36 or sham-EA, repeated over 10 days. The increase in ACTH and corticosterone observed in stress-only rats was prevented in EA St36 animals, and the effects remained intact 4 days after withdrawal of EA but continuation of cold stress. When the GR was blocked with RU-486, the efficacy of EA St36 remained unchanged. GR blockade did significantly elevate ACTH, which is not seen with EA St36, suggesting that EA St36 does act centrally. The elevated HPA hormones in stress-only rats were associated with a significant increase in depressive and anxious behavior; this was not observed in the stressed EA St36 animals. The results indicate that EA specifically at St36 vs sham-EA is effective in treating chronic poststress exposure.

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COMENTARIO

El estudio publicado en la prestigiosa revista Endocrinology proporciona la evidencia más clara existente hasta ahora sobre el papel del estrés crónico en la percepción del dolor. La acupuntura puede reducir el estrés y el dolor y han comprobado como la estimulación con electroacupuntura en el punto E36 del Meridiano del Estómago atenúa... + Leer más

El estudio publicado en la prestigiosa revista Endocrinology proporciona la evidencia más clara existente hasta ahora sobre el papel del estrés crónico en la percepción del dolor. La acupuntura puede reducir el estrés y el dolor y han comprobado como la estimulación con electroacupuntura en el punto E36 del Meridiano del Estómago atenúa la actividad del eje hipotálamo-hipofisario o vía del estrés crónico, también asociado al dolor crónico, el sistema inmune, el humor y las emociones. Algunos antidepresivos y ansiolíticos actúan de la misma forma

IAGS

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