REVISTA

Interacción sinérgica entre la trimetazidina y ketoprofeno en ratones

Valoración Valoración: 3 Estrellas

Descripción: Artículo que expone el posible efecto antinociceptivo por la acción sinérgica de la trimetazidina y el ketoprofeno en ratones.

TITULO FUENTE ORIGINAL:

Synergistic interaction between trimetazidine and ketoprophen in mice

AUTORES:

Daniela CA, S Beşchea, Monica N, A Vasincu, Oana A, Veronica B

REVISTA ABREV.:

Medicamentul Veterinar / Veterinary Drug

AÑO:

2015

REFERENCIA:

9(1): 53–58

FECHA DE PUBLICACIÓN:

01/06/2015

RESUMEN ORIGINAL:

Recent studies have demonstrated the antinociceptive, anti-inflammatory, and gastric protective effects
of trimetazidine (TDZ) on various models in rats. The present study proposes to demonstrate the
antinociceptive action in mice, evaluated in conditions of inflammatory pain, together with the
determination of the type of pharmacodynamic interaction between trimetazidine and...
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Recent studies have demonstrated the antinociceptive, anti-inflammatory, and gastric protective effects
of trimetazidine (TDZ) on various models in rats. The present study proposes to demonstrate the
antinociceptive action in mice, evaluated in conditions of inflammatory pain, together with the
determination of the type of pharmacodynamic interaction between trimetazidine and ketoprofen (KETO).
In this study we used as experimental model of nociception the abdominal constrictive response
(writhing test), induced with Zymosan A in mice, and for the study of the interaction we used as
quantitative evaluation method the method of binary combinations in fixed proportions. The experimental
results allowed the demonstration of the ED 50 for ketoprofen (DE50 = 0.606 ± 0.108 mg/kg) and the
demonstration of the synergism for the associated substances. (Zadd = 1.818 ± 0.326 mg/kg, Zmix = 0.
458 ± 0.101 mg/kg, γ = 0.251, Tc = 4.928, Tt = 3.84, P< 0.05). The results demonstrate that for the same
level of activity (50%), smaller doses of each substance can be used, compared to the doses of the
substances administered alone, which might contribute to a reduction in the number or severity of
adverse effects. on the other side, the demonstration of the synergism might contribute to the
clarification of the action mechanisms. The experiments presented below were made in agreement with
the rules and regulations concerning the work with lab animals.

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