REVISTA

Hiperalgesia inducida por tramadol y su prevención con ketamina en ratas

Descripción: El opioide tramadol puede provocar hiperalgesia en la rata no intervenida pero este efecto puede prevenirse con la ketamina

TITULO FUENTE ORIGINAL:

Tramadol-induced hyperalgesia and its prevention by ketamine in rats: A randomised experimental study.

AUTORES:

Abreu M, Aguado D, Benito J, García-Fernández J, Gómez de Segura IA

REVISTA ABREV.:

Eur J Anaesthesiol

AÑO:

2015

DOI:

10.1097/EJA.0000000000000296

RESUMEN ORIGINAL:

BACKGROUND: Opioid analgesia not only reduces inhalational anaesthetic requirements but may also induce delayed hyperalgesia, with potential effects on the minimum alveolar concentration (MAC) of inhalational anaesthetics. OBJECTIVES: The objective of this study was to evaluate the development of tramadol-induced hyperalgesia and the associated changes in MAC, and whether... + Leer más

BACKGROUND: Opioid analgesia not only reduces inhalational anaesthetic requirements but may also induce delayed hyperalgesia, with potential effects on the minimum alveolar concentration (MAC) of inhalational anaesthetics.

OBJECTIVES: The objective of this study was to evaluate the development of tramadol-induced hyperalgesia and the associated changes in MAC, and whether ketamine prevents both processes.

DESIGN: A prospective, randomised, experimental study.

SETTING: Experimental Surgery Unit, La Paz University Hospital, Madrid, Spain.

ANIMALS: Thirty-nine adult male Wistar rats.

INTERVENTIONS:
Mechanical nociceptive thresholds (MNT) were determined up to 21 days after the intraperitoneal administration of a single dose of tramadol (50 mg kg) with or without ketamine (10 mg kg), or 0.9% saline. The MNT and the MAC of sevoflurane were also assessed in a second experiment before, early (30 min) and 7 days after drug administration with the same treatments.

MAIN OUTCOME MEASURES:
The MAC and MNT were evaluated. The analysis of variance (ANOVA) test was employed to determine differences between treatments and times on MAC and MNT.

RESULTS: Tramadol, alone or combined with ketamine, produced an early increase in MNT. However, tramadol given alone decreased MNT from day 1 up to 3 weeks, which was associated with an increase in the MAC of sevoflurane (P < 0.05; day 7). Ketamine administration prevented both the reduction in MNT and the increase in MAC (P > 0.05).

CONCLUSION: Tramadol-induced hyperalgesia in the rat lasted for several weeks and was associated with an increase in the MAC of sevoflurane. Prior administration of ketamine blocked both phenomena.

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