REVISTA

Implicación de la genética en la analgesia perioperatoria en personas

Valoración Valoración: 4 Estrellas

Descripción: La base genética del paciente puede condicionar la percepción del dolor, la farmacocinética y la farmacodinamia de los fármacos analgésicos, entre otros factores.

TITULO FUENTE ORIGINAL:

Genetics and implications in perioperative analgesia.

AUTORES:

Trescot AM.

REVISTA ABREV.:

Best Pract Res Clin Anaesthesiol.

AÑO:

2014

REFERENCIA:

Jun;28(2):153-166.

DOI:

10.1016/j.bpa.2014.03.004.

FECHA DE PUBLICACIÓN:

01/07/2014

RESUMEN ORIGINAL:

The wide range of patient responses to surgical pain, opioids, and anesthetic agents has puzzled anesthesiologists for many years. Much of the variation has been attributed to differences in patient size, technique, or prior drug use. However, recent genetic testing has revealed exciting clues into the basis for these variances, allowing us to start to predict which patients may have... + Leer más

The wide range of patient responses to surgical pain, opioids, and anesthetic agents has puzzled anesthesiologists for many years. Much of the variation has been attributed to differences in patient size, technique, or prior drug use. However, recent genetic testing has revealed exciting clues into the basis for these variances, allowing us to start to predict which patients may have difficulties and start to select medications more rationally.

In this manuscript, we discuss genetics and pain perception, genetic predisposition to pain, drug metabolism interactions, ethnogenetics, opioid metabolism, opioid receptors, genetic-related peri-anesthetic toxicity, as well as a clinical approach and a discussion regarding the future of genetic testing and anesthesia.

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