REVISTA

Infusión continua intravenosa de lidocaína en vacas anestesiadas con xilacina, ketamina, midazolam e isoflurano

Descripción: La lidocaína en infusión continua intravenosa disminuye la frecuencia cardíaca en vacas sanas

TITULO FUENTE ORIGINAL:

Cardiovascular effects of a continuous rate infusion of lidocaine in calves anesthetized with xylazine, midazolam, ketamine and isoflurane

AUTORES:

Araújo MA1, Dias BP, Bovino F, Deschk M, Abimussi CJ, Oliva VN, Rodrigues CA, Santos PS.

REVISTA ABREV.:

Vet Anaesth Analg.

AÑO:

2014

REFERENCIA:

Mar;41(2):145-52.

DOI:

10.1111/vaa.12102.

RESUMEN ORIGINAL:

OBJECTIVE:
To assess the cardiovascular changes of a continuous rate infusion of lidocaine in calves anesthetized with xylazine, midazolam, ketamine and isoflurane during mechanical ventilation.
STUDY DESIGN:
Prospective, randomized, cross-over, experimental trial.
ANIMALS:
A total of eight, healthy, male Holstein...
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OBJECTIVE:
To assess the cardiovascular changes of a continuous rate infusion of lidocaine in calves anesthetized with xylazine, midazolam, ketamine and isoflurane during mechanical ventilation.
STUDY DESIGN:
Prospective, randomized, cross-over, experimental trial.
ANIMALS:
A total of eight, healthy, male Holstein calves, aged 10 ± 1 months and weighing 114 ± 11 kg were included in the study.
METHODS:
Calves were administered xylazine followed by ketamine and midazolam, orotracheal intubation and maintenance on isoflurane (1.3%) using mechanical ventilation. Forty minutes after induction, lidocaine (2 mg kg⁻¹ bolus) or an equivalent volume of saline (0.9%) was administered IV followed by a continuous rate infusion (100 μg kg⁻¹ minute⁻¹) of lidocaine (treatment L) or saline (treatment C). Heart rate (HR), systolic, diastolic and mean arterial pressures (SAP, DAP and MAP), central venous pressure (CVP), mean pulmonary arterial pressure (mPAP), pulmonary arterial occlusion pressure (PAOP), cardiac output, end-tidal carbon dioxide (Pe'CO2 ) and core temperature (CT) were recorded before lidocaine or saline administration (Baseline) and at 20-minute intervals (T20-T80). Plasma concentrations of lidocaine were measured in treatment L.
RESULTS:
The HR was significantly lower in treatment L compared with treatment C. There was no difference between the treatments with regards to SAP, DAP, MAP and SVRI. CI was significantly lower at T60 in treatment L when compared with treatment C. PAOP and CVP increased significantly at all times compared with Baseline in treatment L. There was no significant difference between times within each treatment and between treatments with regards to other measured variables. Plasma concentrations of lidocaine ranged from 1.85 to 2.06 μg mL⁻¹ during the CRI.
CONCLUSION AND CLINICAL RELEVANCE:
At the studied rate, lidocaine causes a decrease in heart rate which is unlikely to be of clinical significance in healthy animals, but could be a concern in compromised animals.

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