REVISTA

Medetomidina intraperitoneal como analgesia en oveja gestante.

Descripción: La administración de medetomidina mediante bomba osmótica intraperitoneal produce adecuada analgesia en ovejas.

TITULO FUENTE ORIGINAL:

Intraperitoneal medetomidine: a novel analgesic strategy for postoperative pain management in pregnant sheep.

AUTORES:

Murdoch FR, Maker GL, Nitsos I, Polglase GR, Musk GC.

REVISTA ABREV.:

Lab Anim.

AÑO:

2013

REFERENCIA:

Jan;47(1):66-70.

DOI:

10.1177/0023677212473712.

FECHA DE PUBLICACIÓN:

01/01/2013

RESUMEN ORIGINAL:

The absorption of medetomidine released by continuous infusion from an osmotic pump in the abdominal cavity was studied in pregnant sheep during the 24 h postoperative period. Additionally pain and sedation was assessed. Eleven sheep were studied: six were treated with a medetomidine loaded osmotic pump delivering 10 µL/h (3 µg/kg/h medetomidine); and five with a saline... + Leer más

The absorption of medetomidine released by continuous infusion from an osmotic pump in the abdominal cavity was studied in pregnant sheep during the 24 h postoperative period. Additionally pain and sedation was assessed.

Eleven sheep were studied: six were treated with a medetomidine loaded osmotic pump delivering 10 µL/h (3 µg/kg/h medetomidine); and five with a saline loaded osmotic pump (control). Serial blood samples were taken and analysed to determine plasma medetomidine levels.

Medetomidine was absorbed from the peritoneal cavity and a steady plasma concentration was achieved within 10 h, mean (SD) peak concentration was 2.87 (0.22) ng/mL. Sheep receiving medetomidine analgesia had significantly lower pain scores at 10 h than controls. Four control sheep required rescue analgesia, compared with 0 in the treatment group.

Delivery of 3 µg/kg/h medetomidine by an intraperitoneal osmotic pump to pregnant sheep in the 24 h postoperative period provides adequate plasma concentrations of medetomidine for analgesia without sedation.

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