REVISTA

Los transportadores de glicina como nuevas dianas terapéuticas en la esquizofrenia, la dependencia del alcohol y el dolor

Valoración Valoración: 4 Estrellas

Descripción: Los datos de los modelos preclínicos de dolor actuales sugieren que la inhibición de GLUT1 y / o GLUT2 podrían ser una opción terapéutica contra el dolor neuropático.

TITULO FUENTE ORIGINAL:

Glycine transporters as novel therapeutic targets in schizophrenia, alcohol dependence and pain

AUTORES:

Harvey RJ, Yee BK

REVISTA ABREV.:

Nat Rev Drug Discov

AÑO:

2013

REFERENCIA:

Nov;12(11):866-85.

DOI:

10.1038/nrd3893.

RESUMEN ORIGINAL:

Glycine transporters are endogenous regulators of the dual functions of glycine, which acts as a classical inhibitory neurotransmitter at glycinergic synapses and as a modulator of neuronal excitation mediated by NMDA (N-methyl-D-aspartate) receptors at glutamatergic synapses. The two major subtypes of glycine transporters, GlyT1 and GlyT2, have been linked to the pathogenesis and/or treatment... + Leer más

Glycine transporters are endogenous regulators of the dual functions of glycine, which acts as a classical inhibitory neurotransmitter at glycinergic synapses and as a modulator of neuronal excitation mediated by NMDA (N-methyl-D-aspartate) receptors at glutamatergic synapses. The two major subtypes of glycine transporters, GlyT1 and GlyT2, have been linked to the pathogenesis and/or treatment of central and peripheral nervous system disorders, including schizophrenia and related affective and cognitive disturbances, alcohol dependence, pain, epilepsy, breathing disorders and startle disease (also known as hyperekplexia). This Review examines the rationale for the therapeutic potential of GlyT1 and GlyT2 inhibition, and surveys the latest advances in the biology of glycine reuptake and transport as well as the drug discovery and clinical development of compounds that block glycine transporters.

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COMENTARIO

El interés del artículo radica en el uso de las moléculas en relación al dolor, además contiene imágenes sobre la interación de los diferentes canales y neurotransmisores relacionados con el dolor.