REVISTA

Buprenorfina e hidromorfona en tortugas

Descripción: La hidromorfona, pero no la buprenorfina, podría producir analgesia en tortugas.

TITULO FUENTE ORIGINAL:

Antinociceptive efficacy of buprenorphine and hydromorphone in red-eared slider turtles (Trachemys scripta elegans).

AUTORES:

Mans C, Lahner LL, Baker BB, Johnson SM, Sladky KK.

REVISTA ABREV.:

J Zoo Wildl Med.

AÑO:

2012

REFERENCIA:

Sep;43(3):662-5.

FECHA DE PUBLICACIÓN:

02/10/2013

RESUMEN ORIGINAL:

Despite the frequent clinical use of buprenorphine in reptiles, its antinociceptive efficacy is not known. In a randomized, complete cross-over study, the antinociceptive efficacy of buprenorphine (0.2 mg/kg s.c.) was compared with hydromorphone (0.5 mg/kg s.c.), and saline (0.9% s.c. equivalent volume) in 11 healthy red-eared slider turtles (Trachemys scripta elegans). Additionally,... + Leer más

Despite the frequent clinical use of buprenorphine in reptiles, its antinociceptive efficacy is not known.

In a randomized, complete cross-over study, the antinociceptive efficacy of buprenorphine (0.2 mg/kg s.c.) was compared with hydromorphone (0.5 mg/kg s.c.), and saline (0.9% s.c. equivalent volume) in 11 healthy red-eared slider turtles (Trachemys scripta elegans). Additionally, buprenorphine at 0.1 and 1 mg/kg was compared with saline in six turtles. Hindlimb withdrawal latencies were measured after exposure to a focal, thermal noxious stimulus before and between 3 hr and up to 96 hr after drug administration.

Buprenorphine did not significantly increase hindlimb withdrawal latencies at any time point compared with saline. In contrast, hydromorphone administration at 0.5 mg/kg significantly increased hindlimb withdrawal latencies for up to 24 hr.

These results show that hydromorphone, but not buprenorphine, provides thermal antinociception in red-eared slider turtles.

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