REVISTA

Gabapentina y tolerancia aguda al remifentanilo en ratas

Valoración Valoración: 4 Estrellas

Descripción: La gabapentina potencia el efecto del remifentanilo y puede bloquear la tolerancia a los opioides.

TITULO FUENTE ORIGINAL:

The effects of gabapentin on acute opioid tolerance to remifentanil under sevoflurane anesthesia in rats

AUTORES:

Aguado D, Abreu M, Benito J, Garcia-Fernandez J, Gómez de Segura IA.

REVISTA ABREV.:

Anesth Analg

AÑO:

2012

REFERENCIA:

115(1):40-5

DOI:

10.1213/ANE.0b013e3182542727

RESUMEN ORIGINAL:

BACKGROUND:Tolerance to remifentanil during sevoflurane anesthesia may blunt the ability of this drug to reduce anesthetic requirements. Gabapentin has been shown to be effective in reducing postoperative narcotic usage, a reduction that may be associated with a reduction in opioid-induced tolerance and hyperalgesia. We sought to determine whether gabapentin might prevent the observed acute... + Leer más

BACKGROUND:Tolerance to remifentanil during sevoflurane anesthesia may blunt the ability of this drug to reduce anesthetic requirements. Gabapentin has been shown to be effective in reducing postoperative narcotic usage, a reduction that may be associated with a reduction in opioid-induced tolerance and hyperalgesia. We sought to determine whether gabapentin might prevent the observed acute opioid tolerance (AOT) produced by remifentanil in sevoflurane minimum alveolar concentration (MAC).
METHODS:Wistar rats were anesthetized with sevoflurane and the effects of gabapentin alone on sevoflurane MAC were determined at doses of 150 and 300 mg · kg(-1). In a second experiment, gabapentin 300 mg · kg(-1) was administered before remifentanil (120 and 240 μg · kg(-1) · h(-1)). The MAC was determined before gabapentin administration and 3 more times at 1.5-hour intervals after drug administration to assess AOT. MAC was determined from intratracheal gas samples using a sidestream gas analyzer; tail clamping was used as a supramaximal stimulus. Statistical analysis was performed with the 1-way analysis of variance test.
RESULTS:Remifentanil reduced MAC (2.5 ± 0.2%) by 16% ± 5% and 36% ± 6% (120 and 240 μg · kg(-1) · h(-1), respectively, P < 0.01) with a further reduction produced by coadministration with gabapentin 300 mg · kg(-1) to 39% ± 12% and 62% ± 14%, respectively (P < 0.01 versus remifentanil alone). Gabapentin given alone at 150 and 300 mg · kg(-1) reduced MAC by 26% (both doses, P < 0.01). AOT was observed with remifentanil and characterized by a lower degree of MAC reduction, approximately 1.5 hours later (P < 0.05). However, when remifentanil was administered with gabapentin, the AOT to remifentanil was not observed (P > 0.05).
CONCLUSIONS:Gabapentin reduced the sevoflurane MAC and enhanced the MAC reduction produced by remifentanil. This enhancement may limit AOT in rats.

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DOCUMENTACIÓN

Artículo en pdf: the_effects_of_gabapentin_on_acute_opioid.pdf


ENLACES DE INTERÉS

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