REVISTA

Reducción de CAM de sevoflurano por opioides en ratas

Valoración Valoración: 4 Estrellas

Descripción: Los opioides metadona, morfina, tramadol y butorfanol reducen las necesidades de anestésicos inhalatorios en ratas

TITULO FUENTE ORIGINAL:

Reduction of the sevoflurane minimum alveolar concentration induced by methadone, tramadol, butorphanol and morphine in rats

AUTORES:

Abreu M, Aguado D, Benito J, Gómez de Segura IA

REVISTA ABREV.:

Lab Anim

AÑO:

2012

REFERENCIA:

46(3):200-6

DOI:

10.1258/la.2012.010066

RESUMEN ORIGINAL:

This study aimed to estimate the reduction in the minimum alveolar concentration (MAC) of sevoflurane induced by low and high doses of methadone (5 and 10 mg/kg), tramadol (25 and 50 mg/kg), butorphanol (5 and 10 mg/kg) or morphine (5 and 10 mg/kg) in the rat. A control group received normal saline. Sixty-three adult male Sprague-Dawley rats were anaesthetized with sevoflurane (n = 7 per... + Leer más

This study aimed to estimate the reduction in the minimum alveolar concentration (MAC) of sevoflurane induced by low and high doses of methadone (5 and 10 mg/kg), tramadol (25 and 50 mg/kg), butorphanol (5 and 10 mg/kg) or morphine (5 and 10 mg/kg) in the rat. A control group received normal saline. Sixty-three adult male Sprague-Dawley rats were anaesthetized with sevoflurane (n = 7 per group). Sevoflurane MAC was then determined before and after intraperitoneal administration of the opioids or saline. The duration of the sevoflurane MAC reduction and basic cardiovascular and respiratory measurements were also recorded. The baseline MAC was 2.5 (0.3) vol%. Methadone, tramadol and morphine reduced the sevoflurane MAC (low dose: 31 ± 10, 38 ± 15 and 30 ± 13% respectively; high dose: 100 ± 0, 83 ± 17 and 77 ± 25%, respectively) in a dose-dependent manner. The low and high doses of butorphanol reduced the sevoflurane MAC to a similar extent (33 ± 7 and 31 ± 4%, low and high doses, respectively). Two rats developed apnoea following administration of high-dose butorphanol and methadone. These anaesthetic-sparing effects are clinically relevant and may reduce the adverse effects associated with higher doses of inhalational anaesthetics

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DOCUMENTACIÓN

Artículo en pdf: lab-anim-2012-abreu-200-6.pdf


ENLACES DE INTERÉS

Enlace revista:: http://lan.sagepub.com/content/46/3/200.long