REVISTA

Mecanismos subyacentes a la analgesia producida por los receptores opioides periféricos

Valoración Valoración: 3 Estrellas

Descripción: Revisión sobre los mecanismos moleculares por los que la activación de los receptores opioides periféricos produce analgesia y sus implicaciones clínicas.

TITULO FUENTE ORIGINAL:

Peripheral mechanisms of opioid analgesia

AUTORES:

Stein C, Lang LJ

REVISTA ABREV.:

Curr Opin Pharmacol

AÑO:

2009

REFERENCIA:

9(1):3-8

DOI:

10.1016/j.coph.2008.12.009

RESUMEN ORIGINAL:

Potent and clinically significant analgesic effects can be brought about by opioids acting outside the central nervous system. Injury and inflammation of peripheral tissues leads to increased synthesis, axonal transport, membrane-directed trafficking and G-protein coupling of opioid receptors in dorsal root ganglion neurons. These events are dependent on neuronal electrical activity, cytokines... + Leer más

Potent and clinically significant analgesic effects can be brought about by opioids acting outside the central nervous system. Injury and inflammation of peripheral tissues leads to increased synthesis, axonal transport, membrane-directed trafficking and G-protein coupling of opioid receptors in dorsal root ganglion neurons. These events are dependent on neuronal electrical activity, cytokines and nerve growth factor and lead to an enhanced analgesic efficacy of peripherally active opioids. Leukocytes infiltrating inflamed tissue upregulate signal-sequence-encoding mRNA for beta-endorphin and its processing enzymes. Depending on the cell type and stimulus, the opioid release is contingent on extracellular Ca2+ or on release of Ca2+ from endoplasmic reticulum. Analgesia results from inhibition of sensory neuron excitability and of proinflammatory neuropeptide release.

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Enlace a revista: http://www.sciencedirect.com/science/article/[...]