REVISTA

Levo-bupivacaína epidural en el perro

Valoración Valoración: 3 Estrellas

Descripción: La levobupivacaína a la misma concentración produce un efecto similar a la bupivacaína

TITULO FUENTE ORIGINAL:

Analgesic and motor-blocking action of epidurally administered levobupivacaine or bupivacaine in the conscious dog

AUTORES:

Gomez de Segura IA, Menafro A, García-Fernández P, Murillo S, Parodi EM

REVISTA ABREV.:

Vet Anaesth Analg

AÑO:

2009

REFERENCIA:

2009 Sep;36(5):485-94

DOI:

10.1111/j.1467-2995.2009.00469.x

FECHA DE PUBLICACIÓN:

26/12/2009

RESUMEN ORIGINAL:

OBJECTIVE:
To compare the analgesic and motor-blocking effects of epidurally administered levobupivacaine and bupivacaine in the conscious dog.
STUDY DESIGN:
Prospective, randomized, cross-over study.
ANIMALS:
Six adult female Beagle dogs.
METHODS:
Each animal received three doses of...
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OBJECTIVE:
To compare the analgesic and motor-blocking effects of epidurally administered levobupivacaine and bupivacaine in the conscious dog.
STUDY DESIGN:
Prospective, randomized, cross-over study.
ANIMALS:
Six adult female Beagle dogs.
METHODS:
Each animal received three doses of levobupivacaine or bupivacaine (0.5, 1.0 and 1.5 mg kg(-1); concentrations 0.25%, 0.50%, and 0.75%, respectively) in a total volume of 0.2 mL kg(-1) by means of a chronically implanted epidural catheter. Onset, duration (through pinch response in the sacral, lumbar and toe areas) and degree of analgesia and motor-blocking status was determined with a scoring system and at regular intervals over 8.5 hours before (baseline) and after drug administration.
RESULTS:
Epidurally administered levobupivacaine and bupivacaine had a similar dose-dependent analgesic action with no significant differences in onset (range: 5-8 minutes), duration (bupivacaine: 42 +/- 28, 135 +/- 68 and 265 +/- 68 minutes, and levobupivacaine: 28 +/- 33, 79 +/- 55 and 292 +/- 133 minutes; 0.25%, 0.50%, and 0.75%, respectively) or maximum degree of analgesia. However, levobupivacaine tended to produce a shorter duration of motor block than bupivacaine and the difference in the motor to nociceptive blockade times was significant at the highest dose.
CONCLUSION:
Epidural levobupivacaine produced an analgesic action similar to that of bupivacaine.
CLINICAL RELEVANCE:
Epidural levobupivacaine is suitable for clinical use in dogs, mostly at the highest dose if a high degree of analgesia is required.

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COMENTARIO

Los efectos analgésicos de la bupivacaína son similares a los de la levobupivacaína administrada por vía epidural en el perro, con un menor bloqueo motor cuuando se emplea la concentración más allta del 0,75%