REVISTA

Mecanismos celulares y moleculares del dolor

Valoración Valoración: 5 Estrellas

Descripción: Revisión de los mecanismos moleculares y celulares de detección, codificación y modulación de los estímulos nociceptivos que generan el dolor.

TITULO FUENTE ORIGINAL:

Cellular and molecular mechanisms of pain

AUTORES:

Basbaum AI, Bautista DM, Scherrer G, Julius D.

REVISTA ABREV.:

Cell

AÑO:

2009

REFERENCIA:

Oct 16;139(2):267-84.

DOI:

doi: 10.1016/j.cell.2009.09.028.

FECHA DE PUBLICACIÓN:

27/05/2013

RESUMEN ORIGINAL:

The nervous system detects and interprets a wide range of thermal and mechanical stimuli, as well as environmental and endogenous chemical irritants. When intense, these stimuli generate acute pain, and in the setting of persistent injury, both peripheral and central nervous system components of the pain transmission pathway exhibit tremendous plasticity, enhancing pain signals and producing... + Leer más

The nervous system detects and interprets a wide range of thermal and mechanical stimuli, as well as environmental and endogenous chemical irritants. When intense, these stimuli generate acute pain, and in the setting of persistent injury, both peripheral and central nervous system components of the pain transmission pathway exhibit tremendous plasticity, enhancing pain signals and producing hypersensitivity. When plasticity facilitates protective reflexes, it can be beneficial, but when the changes persist, a chronic pain condition may result. Genetic, electrophysiological, and pharmacological studies are elucidating the molecular mechanisms that underlie detection, coding, and modulation of noxious stimuli that generate pain.

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COMENTARIO DE IGNACIO, ?LVAREZ G?MEZ DE SEGURA

Excelente revisión de acceso libre sobre los mecanismos moleculares y celulares de la nocicepción y el dolor.