REVISTA

Butorfanol y morfina en pogonas y serpientes del maíz

Descripción: La morfina produce analgesia en pogonas mientras que el butorfanol lo hace en serpientes, ambos a mayores dosis que mamíferos.

TITULO FUENTE ORIGINAL:

Analgesic efficacy of butorphanol and morphine in bearded dragons and corn snakes.

AUTORES:

Sladky KK, Kinney ME, Johnson SM.

REVISTA ABREV.:

J Am Vet Med Assoc.

AÑO:

2008

REFERENCIA:

Jul 15;233(2):267-73.

DOI:

doi: 10.2460/javma.233.2.267.

FECHA DE PUBLICACIÓN:

02/10/2013

RESUMEN ORIGINAL:

OBJECTIVE:
To test the hypothesis that administration of butorphanol or morphine induces antinociception in bearded dragons and corn snakes.
DESIGN:
Prospective crossover study.
ANIMALS:
12 juvenile and adult bearded dragons and 13 corn snakes.
PROCEDURES:
Infrared heat stimuli were applied...
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OBJECTIVE:
To test the hypothesis that administration of butorphanol or morphine induces antinociception in bearded dragons and corn snakes.
DESIGN:
Prospective crossover study.
ANIMALS:
12 juvenile and adult bearded dragons and 13 corn snakes.
PROCEDURES:
Infrared heat stimuli were applied to the plantar surface of bearded dragon hind limbs or the ventral surface of corn snake tails. Thermal withdrawal latencies (TWDLs) were measured before (baseline) and after SC administration of physiologic saline (0.9% NaCl) solution (equivalent volume to opioid volumes), butorphanol tartrate (2 or 20 mg/kg [0.91 or 9.1 mg/lb]), or morphine sulfate (1, 5, 10, 20, or 40 mg/kg [0.45, 2.27, 4.5, 9.1, or 18.2 mg/lb]).
RESULTS:
For bearded dragons, butorphanol (2 or 20 mg/kg) did not alter hind limb TWDLs at 2 to 24 hours after administration. However, at 8 hours after administration, morphine (10 and 20 mg/kg) significantly increased hind limb TWDLs from baseline values (mean +/- SEM maximum increase, 2.7+/-0.4 seconds and 2.8+/-0.9 seconds, respectively). For corn snakes, butorphanol (20 mg/kg) significantly increased tail TWDLs at 8 hours after administration (maximum increase from baseline value, 3.0+/-0.8 seconds); the low dose had no effect. Morphine injections did not increase tail TWDLs at 2 to 24 hours after administration.
CONCLUSIONS AND CLINICAL RELEVANCE:
Compared with doses used in most mammalian species, high doses of morphine (but not butorphanol) induced analgesia in bearded dragons, whereas high doses of butorphanol (but not morphine) induced analgesia in corn snakes.

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