REVISTA

La ausencia de endocannabinoides incrementa la ansiedad en ratones

Descripción: Los endocannabinoides endógenos controlan la ansiedad y humor en las personas

TITULO FUENTE ORIGINAL:

Genetic Disruption of 2-Arachidonoylglycerol Synthesis Reveals a Key Role for Endocannabinoid Signaling in Anxiety Modulation

AUTORES:

Brian C. Shonesy, Rebecca J. Bluett, Roger J. Colbran, Sachin Patel

REVISTA ABREV.:

Cell Reports

AÑO:

2014

REFERENCIA:

9, 1644–1653

DOI:

dx.doi.org/10.1016/j.celrep.2014.11.001

FECHA DE PUBLICACIÓN:

30/12/2014

RESUMEN ORIGINAL:

The role of the primary endogenous cannabinoid 2-AG in mood and anxiety regulation is not well understood. Shonesy et al. show that deletion of a primary 2-AG synthetic enzyme, DAGLa, results in anxiety and sex-specific depressive phenotypes, which can be rapidly reversed by pharmacological normalization of endocannabinoid levels. Summary + Leer más

The role of the primary endogenous cannabinoid 2-AG in mood and anxiety regulation is not well understood. Shonesy et al. show that deletion of a primary 2-AG synthetic enzyme, DAGLa, results in anxiety and sex-specific depressive phenotypes, which can be rapidly reversed by pharmacological normalization of endocannabinoid levels.

Summary
Endocannabinoid (eCB) signaling has been heavily implicated in the modulation of anxiety and depressive behaviors and emotional learning. However, the role of the most-abundant endocannabinoid 2-arachidonoylglycerol (2-AG) in the physiological regulation of affective behaviors is not well understood. Here, we show that genetic deletion of the 2-AG synthetic enzyme diacylglycerol lipase α (DAGLα) in mice reduces brain, but not circulating, 2-AG levels. DAGLα deletion also results in anxiety-like and sex-specific anhedonic phenotypes associated with impaired activity-dependent eCB retrograde signaling at amygdala glutamatergic synapses. Importantly, acute pharmacological normalization of 2-AG levels reverses both phenotypes of DAGLα-deficient mice. These data suggest 2-AG deficiency could contribute to the pathogenesis of affective disorders and that pharmacological normalization of 2-AG signaling could represent an approach for the treatment of mood and anxiety disorders.

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ENLACES DE INTERÉS

Artículo (pdf): : http://www.cell.com/cell-reports/pdf/S2211-12[...]

Artículo extendido (pdf): : http://www.cell.com/cell-reports/abstract/S22[...]

Comentario de prensa: : http://news.vanderbilt.edu/2014/12/natural-hi[...]

Inhibidores COX-2 y endocannabinoides: : http://news.vanderbilt.edu/2013/08/vanderbilt[...]