REVISTA

Efectos sinérgicos de la morfina y aspirina en las necesidades de isoflurano en la rata.

Valoración Valoración: 5 Estrellas

Descripción: La aspirina potencia el efecto de la morfina en la reducción de la CAM del isoflurano en ratas, disminuyendo los efectos secundarios de ambos analgésicos al emplearse en conjunto.

TITULO FUENTE ORIGINAL:

Aspirin synergistically potentiates isoflurane minimum alveolar concentration reduction produced by morphine in the rat

AUTORES:

Gomez de Segura IA, Criado AB, Santos M, Tendillo FJ

REVISTA ABREV.:

Anesthesiology

AÑO:

1998

REFERENCIA:

89(6):1489-94

RESUMEN ORIGINAL:

BACKGROUND:The combination of opioids and nonsteroidal antiinflammatory drugs is more analgesic than the summed effect of each drug administered separately. This synergism has been used to obtain analgesia in the postoperative period at doses at which side effects are minimal. The aim of this study is to evaluate the analgesic interaction between aspirin and morphine in the rat during... + Leer más

BACKGROUND:The combination of opioids and nonsteroidal antiinflammatory drugs is more analgesic than the summed effect of each drug administered separately. This synergism has been used to obtain analgesia in the postoperative period at doses at which side effects are minimal. The aim of this study is to evaluate the analgesic interaction between aspirin and morphine in the rat during isoflurane anesthesia. The reduction in minimum alveolar concentration of isoflurane (MAC(ISO)) was used as an objective measure of the analgesic potency of individual drugs and their use in combination.
METHODS:Thirty-seven male Wistar rats were anesthetized with isoflurane in oxygen, and the MAC(ISO) was determined before and after the intravenous administration of aspirin and morphine. Rats were administered morphine alone (1, 3, and 10 mg/kg) or morphine (1 and 3 mg/kg) and aspirin (30 mg/kg). The MAC(ISO) was determined from alveolar gas samples at the time of tail clamp. The duration of MAC(ISO) reduction was recorded.
RESULTS:Aspirin did not have an effect on MAC(ISO), (average, 1.35+/-0.1%), whereas the combination of morphine (1 and 3 mg/kg) and aspirin (30 mg/kg) produced a reduction in the dose of morphine needed to produce the same degree of MAC(ISO) reduction. Actual MAC(ISO+drug) data were as follows: 1 mg/kg morphine, 1.17+/-0.14%; 3 mg/kg morphine, 0.98+/-0.15%; 1 mg/kg morphine plus aspirin, 0.90+/-0.04%; 10 mg/kg morphine, 0.63+/-0.13%; and 3 mg/kg morphine plus aspirin, 0.64+/-0.06%.
CONCLUSIONS:The synergistic effects of aspirin and morphine allow a clinically significant reduction in the requirements of isoflurane and isoflurane plus morphine, and these drug combinations may decrease the side effects associated with the use of single higher, equianalgesic doses of these drugs.

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DOCUMENTACIÓN

Artículo completo en pdf: gomez-de-segura_1998.pdf


ENLACES DE INTERÉS

Enlace revista:: http://anesthesiology.pubs.asahq.org/article.[...]